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November 04.2025
3 Minutes Read

Is Long-Term Melatonin Use Risky? New Study Raises Concerns About Heart Health

Close-up of hand holding melatonin pill focusing on health effects.

Understanding the Risks of Melatonin: A Closer Look

For many who struggle with sleep, melatonin supplements have become a go-to solution, often marketed as a natural remedy to help regulate the body's internal clock. However, a new study unveiled at the American Heart Association’s Scientific Sessions 2025 raises significant concerns about the long-term impacts of these widely accessible over-the-counter products. This research indicates that prolonged melatonin use—characterized as over a year—may correlate with an increased risk of heart failure, hospitalization for heart-related issues, and even death in chronic insomnia sufferers.

The Findings: What the Latest Research Reveals

The study involved an extensive review of health records from over 130,000 adults diagnosed with insomnia. The research highlighted that those who had been on melatonin for an extended period had noticeably higher rates of heart failure and associated complications. Although the study establishes an association rather than a direct cause-and-effect link, it undoubtedly warrants further examination. Lead researcher Dr. Ekenedilichukwu Nnadi emphasized that melatonin may not be the harmless sleep aid it’s presumed to be, potentially transforming how healthcare providers counsel patients struggling with sleep issues.

Unpacking Cardiovascular Risks

Heart failure remains alarmingly common, affecting approximately 6.7 million adults in the U.S., as noted by the American Heart Association’s 2025 Heart Disease and Stroke Statistics. Heart failure occurs when the heart struggles to pump sufficient oxygen-rich blood throughout the body, with various underlying causes including hypertension and lifestyle choices. The connection between melatonin and heart issues adds another layer to the understanding of cardiovascular health.

Natural Sleep Aids and Their Potential Benefits

While melatonin is a synthetic form of a naturally occurring hormone produced by the pineal gland, including nutrient-dense foods can also support sleep health. Heart-healthy choices such as salmon, leafy greens, nuts, and berries not only improve overall well-being but can also promote better sleep quality. These foods provide an array of antioxidants and other compounds that support cardiovascular health, emphasizing the importance of a holistic approach to sleep challenges.

The Value of Vigilance: What This Means for You

The findings compel individuals who use melatonin for sleep to critically assess their treatment options. It's vital to discuss any long-term supplement use with healthcare providers who can offer personalized advice and guidance. Instead of solely relying on melatonin, incorporating a variety of heart-friendly foods into one's diet can significantly benefit not only sleep quality but overall cardiovascular performance.

Future Directions: Redefining Sleep Support

As more studies emerge, healthcare professionals must prioritize research on melatonin's long-term effects. Understanding these risks can lead to more comprehensive guidelines for treating sleep disorders. Empirical data on the effectiveness and potential side effects can empower individuals to make informed decisions about their health, balancing between effective sleep solutions and cardiovascular safety.

In light of this new information on melatonin, it’s essential to adopt a proactive stance regarding heart health. By choosing heart-healthy foods, practicing regular exercise, and engaging with healthcare practitioners about supplement use, individuals can significantly enhance their well-being and longevity.

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